The paper introduces the main types of geothermal resource and the structure of the reservoir as well as the reservoir and geographical distribution in Guizhou, describes the current drilling technology and major equipments used for deep geothermal drilling, including well structure, commonly-used drilling rig, bottom hole assembly, commonly-used mud and solid control system, drilling fluid and the research situation of cementing technology. The existing problems of geothermal drilling in Guizhou are analyzed, and the suggestion of introducing new technology and new equipment is put forward.