The strata are brittle, hard and fragile in Xiarihamu mining area, which has certain representativeness in Qimantage key metallogenic belt of Qinghai. Many problems such as short bit life, low drilling efficiency and hole accidents often occur in the drilling process. According to the strata characteristics and drilling difficulties and based on the summary of drilling experience, analysis is made on bit and parameter selection, drilling rig selection and efficiency analysis, drilling tool vibration and dispose, hole wall protection and plugging and hole structure design and construction, comprehensive technical measures are also put forward.