Geothermal resources is a clean energy, which is mainly exploited with geothermal well. The quality and service life of the well will directly affect the whole operation cost and efficiency of heating, spring bathing, planting and breeding. The reduced water amount even no water will occur because of the blockage in filter tubes or mining layers (fissures or karst). These blockage types can be divided into physical and chemical (bacterial) blockage. The causes of various types of blockage are analyzed in detail and the special solutions are proposed according to those different engineering cases.