There are many factors that affect the settlement of the landfill site foundation and the MSW body, great difference exists between direct use of the calculation method of the current standard and the actual actual practice. In order to reduce the influence of uneven settlement on the impermeable layer of landfill, determine the refuse storage and ensure the stability of the garbage heap, it is necessary to make research on settlement of MSW landfill site. The settlement of the landfill site includes the settlement of foundation and the settlement of MSW, and the latter is divided into main settlement and the second settlement, the main settlement time is shorter than the secondary one. Through the settlement calculation of the foundation soil of a landfill site in Baoji City, the maximum settlement difference is more than 100mm, which has a great adverse effect on impermeable layer of landfill site, and for the calculation of the settlement of MSW body, the modified calculation value is very close to the observed value of settlement. Considering the difference of the regions and the garbage composition, the accumulation of observed data is of great significance.