The drilling construction situation of large angle inclined hole in Zara golden deposit in Eritrea is introduced. The practice and exploration are carried out on the requirements of hole deviation control technology, hole wall protection and plugging in complex formation, drilling efficiency improvement in slipping formation and some more drilling technologies. Rational configuration of bottom-hole assembly, washing fluid using technology, drilling parameter selection and bits selection are demonstrated. The exploration process and construction experience will be the foundation of similar projects in the future.