The target section of Yong 553 block in Yong’an oilfield is Sha-4, low permeability reservoir mainly containing glutenite and conglomerate. There are problems such as low drilling efficiency, low exploitation degree and poor economic benefit in early construction. To realize overall high quality and efficient development in Yong 553 block of Yong’an oilfield, IMP was carried out. The overall development program was designed for low permeability 553 block according to the development status and difficulties. By optimizing drilling design, the drilling efficiency was obviously improved with higher quality of wellbore and longer service life of oil well. The successful practice of IPM in Yong 553 low permeability block shows that IPM drilling model is an effective way to improve the quality of oil well, save drilling cost and increase economic efficiency.