Shengtuo oilfield is the matured oil areas of Shengli oilfield. Oilfield development entered the later period, formation pressure disturbance is very common due to long period of waterflooding development, and the deployment of dense well pattern. To maintain the stable production, drilling infill wells in the existing well field. There is anti-collision and barrier-bypassing, wellbore trajectory control and drilling well control and other technical difficulties on infill wells, therefore, according to the actual drilling situation to develop technical plan and emergency plan, anti-collision wells use the "cone bit PDM BHA, pressure relief by stopping early water injection in injectors. Take one group (five wells) and one well as examples, engineering plans, wellbore trajectory control, BHA optimization and well control technology are analyzed, and corresponding measures are proposed, which solve the construction difficulties. The applications prove the scientific and feasible of the measures, and provide reference function for same kind of drilling in matured oilfield.