Thin and medium-thickness coal seams are developed commonly in Guizhou, the geologic conditions of coalbed methane (CBM) exploration are complicated and special. Based on the analysis on the characteristics of coal seams development in Guizhou, the technology of full-zone and multi-stage fracturing was suggested. Several fractured segments are optimized in one same well, each segment comprises a plurality of adjacent coal seams and interlays between coal seams. Construction difficulty can be reduced by ball plugging and sand filling & sealing. Full-zone and multi-stage fracturing technology has been applied in CMB ground development demonstration project of Songhe mine of Liupanshui coalfield with some success.