Wall protection and plugging has been technical difficulty in deep hole drilling. In the drilling construction for deep prospecting projects in Xiaoqinling, because of the complex regional geology with tectonic development and fractured rocks, block falling, hole collapse and leakage often occurred in drilling process and mud plugging effect was poor, while good result was achieved by slurry plugging in the construction. According to the application of cement slurry plugging technology for deep drilling projects in Xiaoqinling, the paper analyzes and summarizes wall protection and plugging technology for deep core drilling, puts forward the requirements of deep holes grouting and plugging technology to the performance of quick-setting cement slurry and gives advices to the related drilling construction in this area.