Through the analysis on the construction conditions, the drill pipe breaking accidents and the broken parts in the geographical survey well in Tonghua Basin, and on the basis of drill pipes and drilling parameters, the thread stress of the drill pipe joint was calculated. The modeled thread connection part of drill pipes was established by means of SolidWorks, which was then introduced into Ansys Workbench for stress and fatigue simulation analysis to predict the fatigue life of the drill pipe joint. Based on the analysis on simulation results and combined with the geological core cataloging and logging data, the causes of the drill pipe breakage occurring under the conditions of gushing water with a large amount of gas are discussed and the drilling parameters are optimized to reduce the occurrence of the drill pipe breakage in the hole.