As the largest hard rock type of recoverable uranium deposits base in China, Zoige uranium ore is the key ready exploration area for “358”goal in national geological prospecting. But it is in high altitude area with fragile ecological environment, strata structure development, short construction season, frequent layer changes, strong deviating force, fissures development and brittle and broken rocks, which cause a series of problems of serious bit wear or eccentric wear, low drilling efficiency and short bit service life. According to the characteristics of the formation and based on the preliminary test and the analysis on rock property, diamond bits of different structures are developed and are tested in 5 drilling holes. The tests show that the improved diamond bits have significant increase in drilling efficiency and average bit service life. Compared with the drilling data of 2014, the average drilling efficiency and bit service life are increased by 33.7% and 132% in 2015 respectively; the expected target of experiment is reached.