Oilfield YD is one of marine strata carbonate reservoir in Middle East, active heterogeneous asphaltene heavy oil are distributed in Kazh formation with high pressure and acidic gas; being non-target layer, Kazh formation should be drilled through and isolated, then the lower payzone can be developed. Uneven distribution of asphaltene heavy oil and uncertain pore pressure bring severe challenges to drilling construction. Because of asphaltene heavy oil intrusion, 3 wells had to be abandoned in the first phase construction. In view of this world difficult problem, the technical study was made with some results. This paper discusses the experimental study on the intrusion mechanism of asphaltene heavy oil, the development of hardening agent, the application of managed pressure drilling technique and a series of associated technology research, proposes the safe drilling measures for asphaltene heavy oil layer and presents the field application effects.