Wudi-1 is a geological survey well in Ermahu depression of Wuwei basin and the drilling project is located in the hinterland of Inner Mongolia Autonomous Region Tengger Desert with bad construction conditions. The main lithologies of upper Quaternary overburden are yellow sand and red fine sand with large thickness, being loose and easy to collapse. According to the drilling difficulties of Wudi-1, the measures were taken in site construction, drilling equipments selection, casing program, and drilling fluid, the experience has been accumulated for drilling construction in desert area.