Wire-line core drilling is prone to the problems such as lost circulation, borehole collapse and coring difficulty in complex structural belt, some improper handling or even leads to hole being abandoned. This paper introduces the construction difficulties of wire-line core drilling in complicated area with the example of Niu D1 well, and analyzes the inducing factors of lost circulation and borehole collapse, as well as the reasons for coring difficulties; then points out the reasons why the conventional anti-collapse and plugging technologies can not meet the needs of drilling construction in complex structural belt, and puts forward some operational specific improvement measures to optimize drilling fluid, optimize drilling assembly and improve plugging process. The experience summary of Niu D1 well construction could be the reference for the future construction of wire-line core drilling in complex structural belt.