With the case of project supervision of “Beijing Karst water resources exploration and evaluation project”, through the comparative analysis on karst water exploration construction supervision and construction engineering, municipal and water conservancy and hydropower project as well as petroleum drilling project supervision, according to the characteristics of construction supervision for Karst water exploration and combined with the previous supervision experience, the contents and precautions of supervision and engineering control of karst water exploration project are put forward to ensure the smooth implementation of drilling construction supervision for Beijing Karst water resources exploration and evaluation project. This research provides the train of thought and the reference for this kind of project supervision and engineering control.