Well leakage brings not only losses to drilling engineering, but also great difficulties to the exploration development of oil gas resources. Permian igneous rock developed in the northern part of Shunbei area with formation fractures, leakage in drilling process is the main complex downhole situation. At present, Permian leakage happens frequently, which causes collapsing and block falling and has adverse effects on construction progress. To solve this problem, the research on plugging while drilling technology for Permian in Shunbei area is carried out. Combined with the drilling practice of wells SHB 1-1, SHB 1-5 and SHB 1-6 and considering Permian strata characteristics, this paper analyzes the drilling difficulties of Permian in this block and summarizes the concrete construction methods of plugging while drilling technology. In order to cope with the possible large leakage, plugging formulas are optimized for the boards with seams of 1, 3 and 5mm respectively.