In shale gas geological survey well construction in Tongren of Guizhou, because of the complex strata structure with development of karst and dissolution in the upper limestone strata, the wall is prone to collapse with block falling and drill pipe sticking, serious leakage and difficult water supply. The depth of Xiuye2 well was designed for 1900m, but this well was halfway abandoned due to the serious lost circulation, block falling and drill pipe sticking in the process of cement slurry sealing and plugging. After drill shifting, the scheme of hole opening with large diameter, multi-stage wire-line core drilling, sublevel cementing plugging and wall protection by multi-layer casing was adopted, the hole construction was completed smoothly. This paper summarizes the drilling experience mainly in cement sealing and plugging to provide reference to shale gas well construction in this area.