The coal-bearing strata are mostly gray and yellowish conglomerate, sandstone, mudstone, mudstone and glutenite interbedded, mudstone intercalated coal seam or coal line in the eastern exploration area of Naomaohu coalfield in Xinjiang, among which, strata of mudstone, mudstone and glutenite interbedded have strong water sensitivity, poor cementation and are easy to cause hydrated swell, shrinkage and wall collapse in the drilling process, wall protection is difficult. In view of the characteristics of the mine strata, the inhibitory solid free and low solid drilling fluid are used, the borehole stability is kept and effective and safe drilling is realized.