In the water supply well of Kouzhuang station of shenshuo railway, the unsatisfactory water-sealing effect greatly influences the water quality. Aiming at the problems in water-sealing and plugging, plugging and grouting technology with upper and lower packer is put forward under the condition of well completion; the water quality turbidity is solved. The practice shows that this technology is simple in construction and flexible in use with good water-sealing effect.