The drill string is the most important connecting link in deep exploration, and it is prone to experience failure due to complicated loads with long time working in wellbores full of drilling fluid, corrosion, wear, temperature and so on, leading to great economic loss. Investigation has found that vibration is the main cause of drill string failures; however, besides vibration, drill string failures are also caused by other factors, such as drill string quality, human acts, wellbore quality, running in of casing, inclination measurement, drilling fluids in deep geological drilling. This paper proposes the corresponding preventive measures for these influencing factors. It is emphasized that with the increase of deep geological drilling depth, geological drilling string dynamics research will become more and more important, and should be strengthened to ensure the smooth progress of deep geological drilling with all round consideration of influencing factors for geological drilling string failures.