With the breakage of ore-bearing layer in Yangshishan gold deposite prospecting drilling in Yunnan, but coring reqirements are high, low core recovery rate and frequent downhole accidents often happen when drilling using 110mm single pipe. A set of drilling technology which combines 110mm single pipe drilling with 95mm wire-line coring is explored, the drilling difficulties in fractured ore bearing layers are solved and core recovery rate is ensured.