Shale gas formation is characterized by high hardness, high brittleness, high drillability, leading to low PRM, less footage per run and low core recovery. Based on the field practice of Quancan Well-1, this paper sums up the experience of large diameter one-pass well coring and completion. In the process of drilling, the drilling parameters were adjusted reasonably, and the core drill bit and coring accessories were specifically selected with the coring run increased to meet the relevant requirements of the sampling test. The core drilling efficiency was improved by combining rotary table + PDM drilling, and the drilling cost was reduced by a certain extent.