The northwest Jiaodong Hongbu gold deposit located in the middle Jiaojia gold field, but not a typical Jiaojia style gold mine, is a fine net vein gold deposit developed in the granite (diorite) on both sides of the fault zone and controlled by dense cleavage and fractures. Because it is controlled by three major faults, namely the main Jiaojia fault, the Hexi fault and the Houjia fault of the Jiaojia fault system, the geological structure encountered in drilling is extremely complex. In this paper, application of chemical gel plugging agents in Borehole-127ZK1, the deepest hole in the mine is described.