The geological survey drilling project in the Keping area of the Tarim Basin-Well Xinsudi1 is located on the Shajingzi tectonic belt of the Awati depression in the Tarim Basin. The structural belt is featured of a large inclination, poor cementation, serious breakage and the stability of the borehole wall is poor. The lithology encountered during drilling was mainly mudstone, sandstone, argillaceous siltstone, limestone, dolomite, mud-bearing dolomitic rock, quartz schist and so on. There were many collapses and circulation loss. Use of the polymer anti-collapse drilling fluid system on the site has solved the complex problems such as broken formation, collapse, falling stones. The system provided strong inhibition and good cementation, and achieved good performance in borehole wall protection leakage plugging, ensuring successful implementation of the project.