According to the long-term deep drilling experience, this paper analyzes the main criteria and principle of deep geological drilling design. Through typical cases of deep drilling structure design and implementation, a few drilling structure implementation procedures are summarized. First, for the familiar mine where geological prediction is not far from the reality, drilling can be performed as the experience-based design. Second, if the complex conditions of the lower strata cannot predicted, the exploratory method is adopted, including pilot drilling combined with reaming, adjustment of the drilling structure according to the actual situation. Third, larger diameter drilling should proceed as deep as possible. It may provide some experience reference for the structure design and construction of deep holes and ultra-deep holes.