In the context of geothermal drilling equipment and well structures in Guizhou Province, the application of air-lift reverse circulation drilling technology in geothermal well drilling is summarized, including the direct mud circulation and air-lift reverse circulation principles, drilling equipment, BHA, immersion ratio, drilling parameters and so on. The field results of air-lift reverse circulation drilling technology in geothermal well drilling proved that it can improve the drilling efficiency in dissolved fractured formation, reduce incidents down the holes. At the same time, this technology provides good borehole cleaning in thermal reservoirs.