Exploration and production wells need to achieve the dual purpose of accurately obtaining hydrogeological parameters and solving the problem of drinking water for the people. Therefore, when rotary drilling technology is adopted, the flushing fluid is required not only to have basic wall protection and anti-collapse functions, but also to minimize the impact on formation permeability, and also to have good environmental protection.. According to this special requirement, a new PA-1 type solid-free flushing fluid solution was developed, also, the permeability test, SEM and sand ball immersion test were used to evaluate and analyze the flushing fluid in the laboratory, The results show that PA-1 solid-free flushing fluid has little influence on formation permeability and strong ability to prevent collapse, Which comprehensive performance is superior to the conventional flushing fluid system; In addition, the acute toxicity test of Chinese rice shrimp showed that it was safe and non-toxic. Therefore , a large number of laboratory experiments and field applications show that PA-1 solid-free flushing fluid has excellent performance,which can provide a reference for the selection of flushing fluid in Exploration and production well construction in the future.