Oil shale (shale gas) Well Sanye1 in Xinjiang Santanghu Basin was designed with depth of 1750m and full hole coring. In the drilling process, there were some problems such as wellbore contraction, collapse and drilling difficulty in winter, and so on. Through the adoption of the polymer film-forming mud system, special coring drilling tools and other technical measures as well as specific drilling management measures, the drilling technical problems have been effectively solved. It provides high quality physical data for the investigation and evaluation of oil and gas resources in this area.