The requirement on the quality control in the technical specifications is very strict for drilling of the solution mining intersected well sets at Kazan Trona Mine. The vertical wells were easily deviated, with low core recovery and poor cement bonding due to the complex geology, the high dip angle of the formation, and presence of several aquifers; meanwhile, for the horizontal well, it was very difficult to control the trajectory. After a thorough analysis of data obtained from previously drilled wells and a study of related issues and optimization of solutions, several measurements were put forward and applied. The results showed that all the drilling problems were effectively solved, the drilling process was improved, and the construction period was reduced. The experience acquired from the project could be used as reference for the similar works.