Sichuan-Tibet Railway is a most challenging project in the history of railway construction. The geological conditions along the railway are complex， and the internal and external dynamic geological disasters are extremely developed. In view of the possible engineering hazards such as rock burst， water gushing， and rock radioactivity， a large number of in-hole tests should be carried out for the Sichuan Tibet Railway investigation project， including in-situ stress test， hydrological test， ground temperature test， comprehensive logging. Taking Borehole DZ-S-04-1 as an example， this paper introduces in detail the in-hole test items and borehole quality control plan for the investigation hole for Sichuan-Tibet Railway. With careful design and construction， Borehole DZ-S-04-1 has been successfully completed together with the in-hole tests， which provides valuable data basis for subsequent construction.