Well JZ04 is a geothermal exploration well in Jizhong depression. As the region’s deepest geothermal exploration well， its drilling design is mainly based on its geological design， adjacent well stratigraphic data and related geophysical data. The detailed design of the well hole structure is conducted through analysis of the regional geological data， with design and selection of the drilling equipment， the drilling stem， the drilling fluid system， the cementing method， well control device and so on. The relevant measures and operation requirements are put forward for reservoir protection. Considering high risk in later drilling operations due to great well depth， complex strata， and compromised accuracy of formation data， the drilling difficulties and the corresponding solutions are given in the design. The design can provide some guide for later drilling operations； hence support for drilling smoothly to the target layer to complete the drilling task.