In view of drilling string wear and low drilling efficiency at total loss of return in deep or horizontal geological drilling, a kind of high efficiency drill pipe grease was developed with the one step method with white oil, sodium based thickener and adhesive material as raw materials, and has achieved remarkable results from field use in horizontal holes along the Changdu section of SichuanTibet Railway, which strongly supported the construction of large displacement horizontal holes on the SichuanTibet Railway. Indoor evaluation and application results showed that the grease has low temperature resistance (-16℃), easy application, good adhesion and lubricity, and high cost performance ratio. It can protect drilling tools for a long time, and its lubricating effect can compares to that of foreign products.