The lithology of the Xiangyangping uranium deposit in Guangxi is mainly granite with strong abrasiveness， and some formation is complex with densely developed structural fissures， broken rocks， strong chloritization and kaolinization， leading to drilling difficulty. With the use of diamond wire line core drilling technology and process， continuous improvement measures have been taken to solve the problems encountered in drilling， such as low drilling efficiency， unstable hole wall， short service life of the diamond bit and bending of the drilling hole. Field practice has proved that the drilling technology and process has the advantages of high drilling efficiency， high core recovery and low labor intensity， which can accumulate valuable experience for drilling of granite and complex strata.