A new kind of nano cement-based plugging material has been developed to meet the actual needs of the performance of wellbore protection materials in deep drilling technology. First， through analyzing the performance results of different types of cement at the same temperature， Grade G oil well cement was determined as cementing material； second， based on the performance defects of deep drilling wellbore protection and plugging material， special fiber and nano materials were used to improve the mechanical properties of cement slurry， and the early strength agent （ZQ） and the water reducer （GB） were selected as additives for orthogonal experiment， which led to the development of the optimum formula of cement based wellbore protection and plugging material. Finally， its main performance was analyzed and evaluated. The results show that the material has good fluidity and excellent mechanical properties， and its comprehensive performance can meet the needs of wellbore protection and plugging in deep drilling.