The WR-1 geothermal exploration well in Henan province is designed for two exploration target zones， the Neogene Guantao Formation and the Ordovician， which is necessary to be completed and tested separately. After the completion of the Guantao Formation well test， it is necessary to continue drilling to complete the Ordovician section. In the design of the wellbore structure， optimization and improvement were conducted on various aspects， including casing design， cementing structure， to address completion tubing string cementing， matching of the wellbore and casing sizes and filter parameter design for the Guantao Formation section， and verified with actual drilling. This paper mainly introduces the key elements that need to be considered and the design process in the design of the geothermal exploration well structure. The design of the well structure was adjusted and optimized in regard to the actual drilling works， so that it will be operable on site and provide theoretical and practical guidance for other similar two geothermal reservoirs exploration wells.