According to the geological needs， XY-6B drill was used to drill a scientific experimental hole with design depth of 535m， and completion depth 540m at ?133mm in the Qipanjing coal mine area， Inner Mongolia. After drilling， geophysical exploration was needed. In order to reduce the shielding of the steel casing to the instrument signal in the drilling hole， PVC-U casing of ?90mm diameter was run into the drilling hole. A lot of preparatory work was done before setting the PVC-U casing， mainly including the diameter parameter design of the drilling hole， modification of PVC-U casing connection mode， use of the guide cone head to prevent the wear and jamming of PVC-U casing during running， processing the screen pipe to balance the buoyancy of drilling mud. As a result， the PVC-U casing was successfully run into the scientific experimental drilling hole， ensuring the smooth completion of a series of scientific experiments.