Compared with the traditional drilling technology， air reverse circulation drilling has the advantages of low cost， fast drilling speed， low site requirements， reliable and non-pollution samples. Because it takes compressed air as the main circulating medium， it is easy to cause blockage when meets water and ice. Therefore， it has been a difficult problem to be applied in the ultra-high altitude area with complex environment such as thin air， thick permafrost and abundant groundwater. In order to verify the feasibility of air reverse circulation drilling technology applied in the complex environment， based on the air reverse circulation drilling project of Julong copper mine in the Tibet autonomous region， this paper has successfully developed a complete set of construction technology to overcome complex environmental factors through the selection of high-power equipment， the improvement of waterproof technology and the application of anti-freezing materials. As a result， its comprehensive efficiency is similar to that of the plain area， and the air reverse circulation drilling technology can be applied to the ultra-high altitude area is proved.