Shengli Jiyang shale oil block is the key development block of Sinopec and the third national shale oil development pilot zone of China， where the geological conditions are complex. Problems exist in the second spud such as shot bit life， less drilling footage， high “supporting pressure” of sliding drilling in the deviated section in the upper gravel layer， and prominent conflict exists between bit aggressivity and tool face stability. In view of the above problems， research was carried out on the optimization of drilling process in sections， optimization of well trajectory， development of efficient bit and matching of speed-raising tools， etc.， and a high-efficiency drilling technology for ?311.1mm large hole of Shengli shale oil was formed. The technology was applied in 20 wells of Niuzhuang depression， which achieves significant results in speed-raising and efficiency improvement. The mechanical penetration rate was increased by 40.8%， the average drilling footage was increased by 46.35% higher than that in the early stage of the same block， and the average drilling cycle of the second spud is shorter by 55.55% compared to that of early stage in the same block， which effectively guarantees the smooth progress of the construction in the national shale oil demonstration area of Shengli Oilfield.