Potassium salt mine is one of the minerals urgently needed in our country. JG-2 well is a geological data survey well arranged in Jinggu sag in order to further identify the potassium salt resources of Mengyejing Formation in Simao Basin， Yunnan Province. The formation lithology is mainly mudstone， sandstone， breccia and stone salt， etc. During the construction， the hydration expansion and spalling of mudstone and breccia caused the safety hazards of shaft wall collapse， diameter reduction and bit balling. Potassium salt rock layer is easy to dissolve， dissolution leads to super diameter， core dissolution， diamond bit in stone salt layer mechanical drilling rate is low， sandstone fracture leakage and other problems. By using the key technology of “Potassium-magnesium-based saturated brine drilling fluid”， improving the bit structure， using PDC bit and using bridge plug plugging method， the problems of core dissolution， leakage， bit balling and low drilling efficiency are better solved. The drilling depth is 1829.44m and the drilling diameter is 133mm. Salt bed core recovery rate of 97.38%， obtained high quality potassium rock core and drilling quality. This paper summarizes the technical experience and existing problems in the smooth implementation of JG-2 well， which can provide reference experience for similar projects in the future.