In recent years， people have paid more and more attention to the development of medium-deep sandstone geothermal resources， and centralized exploitation has gradually become the norm. In the deployment process of centralized sandstone geothermal wells， well spacing and well pattern not only determine the temperature and water level changes of geothermal wells after many years， but also affect the life and economy of geothermal projects. This paper takes the geothermal heating project with an area of 2.3×10⁶m² in Jidong Caofeidian Newtown as an example， the optimization of centralized sandstone geothermal exploitation well pattern is studied. On the basis of geothermal exploration in the study area， the exploitation volume of geothermal wells is 100m³/h and the reinjection volume is 80m³/h. Numerical modeling is used to optimize the well spacing of geothermal production and irrigation wells to 450m， and the well pattern of geothermal production and irrigation wells is arranged in staggered rows. Multi-well pilot test is used to verify the rationality of the production and reinjection volumn of the geothermal well， and the geothermal well production and irrigation operation and maintenance system is formulated to achieve 100% natural reinjection. The water level and temperature changes for many years of the thermal reservoir seepage field are predicted by modeling the production data of the well group. It can provide technical support for large-scale geothermal resource development.