The continuous increase in prospecting depth is a significant feature of mineral exploration. The deepest borehole of Gaodi Manganese Mine in Songtao County， Guizhou Province is 2001.68m and the shallowest is 1486m. The main difficulty of the construction is the prevention of accidents in the hole and the control of the hole inclination. Starting from the drillinig hole design， equipment configuration， drilling technology， drilling parameters and mud configuration， etc.， this paper provide safeguard measures for the advancement of the project. The deflection law， anti-deflection measures and the most effective construction plan of the deep hole drilling of the Gaodi Manganese Mine in Guizhou Province are summerized， and technical opinions are put forward for the future construction of the deep hole drilling of the Manganese Mine in Guizhou Province.