The exploration and drilling of the Nalinggou uranium deposit in the Ordos Basin has some technical problems， such as low heart rate of loose sandstone core， slow drilling efficiency of core-gravel layer， low drilling efficiency of mudstone formation and easy deviation of drilling hole. The project team adopts various technical measures， such as various core mining methods， mud maintenance， optimized use of drill bit and reasonable drilling tool grading. Good results have been achieved in the aspects of keeping straight and preventing deviation， improving the adoption rate， and improving the drilling efficiency of gravel and mudstone， which better solves the above difficulties encountered in the construction， improves the drilling efficiency and drilling quality， and accumulates more valuable experience in sandstone drilling construction， which provides construction experience for the future drilling construction of sandstone type uranium ore in the north of the Ordos Basin.