In order to investigate the lithology and stratigraphy of the Cretaceous-Permian strata in the Wangjiang Depression of the Lower Yangtze Area， verify the geophysical information， and evaluate the petroleum potential， the Wanwangdi 4 well was deployed by the China Geological Survey， which is a large-caliber shale gas geological survey well， and the total depth of which is 2503.9m. To deal with the complex drilling situation of variable formations， soft and hard interlayers， and large sections of multi-layered mudstone layers， drilling technologies such as bit adaptability optimization， inclination correction and reliable drilling fluid system were implemented to achieve anti-deviation and fast penetration， ensure core recovery rate， and achieve the drilling goals. The drilling technology used in this well can provide useful experience for oil and gas drilling in surrounding areas.