As the main drilling structure for sandstone type in-situ leaching uranium mining， the gravel filling structure drilling （one-time well completion process） has been applied in multiple uranium mining areas in China. However， during the application process， problems such as easy blockage and damage of filters， long flushing time required， and short service life of drilling have gradually become prominent. This article analyzes the problems existing in gravel filling structure drilling， and focuses on the reasons for the problems， including the drilling structure. The construction process innovation has been carried out in areas such as grouting technology， mining and aquifer cutting technology， installation of built-in filters， and reverse gravel casting， forming a new type of window cutting and drilling construction technology. In the past two years， the new window cutting drilling construction technology has been applied on a large scale in a uranium deposit in Xinjiang， and the application effect is good， effectively solving the problems existing in the gravel filling drilling construction technology.