In Qinghai， Xinjiang and other arid areas of China， some mining site water is brine with high salt content. For convenience， salt water is used to prepare cement plugging slurry. A set of salt-water cement plugging slurry system for geological drilling is developed through the selection of various cement admixtures， and the conventional and plugging properties have been comprehensively evaluated. The results showed good fluidity， filtration reducing property and sedimentary stability， the early compressive and flexural strength of the system is greater， and the final coagulation time is shorter. 5% sodium chloride shows obvious early strength and promoting coagulation for cement slurry. The thickening time of the system at 30MPa and 45~75℃ is 110~170min， the slurry is stable， and the thickening characteristics are good， which can effectively plug up the orifice and seam plate. The saltwater cement slurry system has a good application prospect in the plugging operation of fractured formation in similar areas.