The construction technology of improving the engineering properties and strengthening the strength of fractured rock mass by grouting reinforcement has been widely used in mining and water conservancy projects. In order to study the related effects of various grouting factors and grouting methods on the strength of fractured rock mass in grouting reinforcement, as well as the effects of freeze-thaw action on the engineering properties of fractured rock mass after grouting reinforcement, cement mortar and other materials are used to make similar materials that can simulate the mechanical properties of fractured original rock according to a certain similarity ratio. By controlling the relative variables of slurry water-cement ratio, grouting velocity (grouting pressure), grouting temperature and other factors, the fractured rock mass is reinforced by grouting with inorganic materials, inorganic composite materials and organic materials respectively. Through the simulation of the climate and other environmental conditions in this area, the relevant tests of various factors are carried out, and then the influence of various factors on grouting reinforcement is analyzed. Finally, according to the test results, the grouting parameters are optimized, and the grouting reinforcement scheme is designed and monitored according to the engineering geological conditions and geological environment of the slope of Zhonglian Runshi open-pit coal mine in Junxixiheishan mining area, Xinjiang, which has certain reference significance for slope disaster prevention and control in this area and other open-pit mines with similar geological characteristics and regional characteristics.