The investigation and evaluation of oil and gas resources in the Qiangtang Basin mainly rely on geological survey wells, and the drilling construction is mainly carried out using rope coring drilling technology. Through continuous exploration and summary, Xizang Geological Team 6 has found a complete set of wireline coring drilling technology that is suitable for severe conditions such as high altitude, cold and low oxygen deep sedimentary rocks in the Qiangtang Basin. The drilling equipment has been upgraded from optimizing and retrofitting traditional mechanical core drilling rigs to customizing and developing new electric top drive direct drive drilling rigs; The coring drilling tool has transitioned from the S series to the Q series, and the main diameter of the rope coring tool has been increased to SQ (150mm), forming a situation where the three major diameters of HQ (96mm), PQ (122mm), and SQ (150mm) share the responsibility; The development of drilling fluid from conventional fine dispersed low solid phase system to a new solid free high inhibition anti pollution cationic system; Drilling plugging has been optimized from conventional inert materials and ordinary cement slurry plugging to anti water invasion early strength cement slurry plugging and original plugging ball plugging.