The drilling of shale gas parameter well-1 of Shandong encountered complex formations with serious mud making in water sensitive formation and collapsed block in Permian strata. The jammed bit accident led to slow drilling construction progress with high risk. According to the technical difficulties in the drilling process, the drilling fluid system for the first and the second as well as the coring sections are determined by a series of technology research to form a complete set of drilling fluid technology and engineering measures. The results show that the difficulties such as collapsed block are solved by this drilling fluid system in the shale gas parameter well-1 of Shandong, the downhole accidents are reduced with improved drilling speed and short well construction period.