To meet the needs of deep prospecting and geoscience research in recent years, the number of drill holes over 2000m depth constantly updated, and core drilling depth records were constantly broken. Due to the higher goal of the deep drilling, the more complex formation-pressure systems, the longer drilling time, lots of the new requirements were put forward in the different regions, such as drilling equipment, technology and management. And each chosen site has different typical technical challenging and difficult problems. SinoProbe-05 project has completed the following drilling works, including Luobusa in Tibet, Jinchuan in Gansu, Tengchong in Yunnan, Luzong and Tongling in Anhui and Yudu in Jiangxi since 2009. Related techniques are introduced in the paper, especially some technical issues, including the total of 10 aspects of equipment, technology and materials etc. Combined with the experience of other projects of SinoProbe in recent years, the paper discusses some drilling risk-proof ways and strategies.