The difference in ground stress has an important influence on the fracture propagation of split grouting. Aiming at the water stoppage in the oil shale in-situ retorting zone, this paper proposes a new method combining directional perforation and split grouting to guide fracture propagation. According to the oil shale parameters, RFPA was used to analyze the influence of perforation on fracture propagation, and further analyze the influence of ground stress difference on fracture propagation with perforation. The results show that compared with non-perforated grouting, perforated grouting can direct splitting and reduce grouting pressure; When the stress in the x direction is greater than the stress in the y direction, a large number of fractures generated between the perforations connect the perforations to form a curtain；When the stress in the x direction is less than the stress in the y direction, as the stress difference gradually increases, the fracture propagation gradually deflects from the x direction to the y direction，until the stress difference becomes the main factor affecting fracture propagation, no fractures are formed between the perforations and the perforations cannot be connected. This study can provide a reference for the water stop project in the oil shale in-situ retorting zone.